BVR - Better Variability Results
نویسندگان
چکیده
We present BVR (Base Variability Resolution models), a language developed to fulfill the industrial needs in the safety domain for variability modeling. We show how the industrial needs are in fact quite general and that general mechanisms can be used to satisfy them. BVR is built on the OMG Revised Submission of CVL (Common Variability Language), but is simplified and enhanced relative to that language.
منابع مشابه
Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis
Beat-to-beat variability of repolarization duration (BVR) is an intrinsic characteristic of cardiac function and a better marker of proarrhythmia than repolarization prolongation alone. The ionic mechanisms underlying baseline BVR in physiological conditions, its rate dependence, and the factors contributing to increased BVR in pathologies remain incompletely understood. Here, we employed compu...
متن کاملProarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation.
OBJECTIVE Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) ...
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This article presents an overview of different measures for beat-to-beat variability of cardiac ventricular repolarization (BVR). Action potential duration (APD), variability of repolarization duration, Poincaré plot area, instability of repolarization and a combined measure are compared on their capabilities for the prediction of susceptibility to arrhythmias. This is done by both statistical ...
متن کاملExperimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition
Beat-to-beat variability in repolarization (BVR) has been proposed as an arrhythmic risk marker for disease and pharmacological action. The mechanisms are unclear but BVR is thought to be a cell level manifestation of ion channel stochasticity, modulated by cell-to-cell differences in ionic conductances. In this study, we describe the construction of an experimentally-calibrated set of stochast...
متن کاملClinical evaluation of acromioclavicular joint pathology: sensitivity of a new test.
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تاریخ انتشار 2014